Publications

Research - Laurent - Members - Publications

143. From Benzofurans to Indoles: Palladium-Catalyzed Reductive Ring-Opening and Closure via β-Phenoxide Elimination
Luca Alessandro Perego, Simon Wagschal, Raymond Grüber, Paul Fleurat-Lessard, Laurent El Kaim and Laurence Grimaud
Adv. Syn. Cat. 2018, Accepted, doi:10.1002/adsc.201801225

142. A Passerini/Michael pathway towards butyrolactones
Shuanglong Jia and, Laurent El-Kaïm
Eur. J. Org. Chem. 2018, Accepted, doi:10.1002/ejoc.201800958

141. Palladium triggered dienes formation from nitro allylic compounds: a versatile entry into naphthalene derivatives
Laurent El-Kaïm, Mansour Dolè Kerim, Shuanglong Jia, Sébastien Prévost and Chrysoula Theodorakidou
Chem. Comm. 2018, Accepted, doi:10.1039/C8CC06536E

140. Proparylation of Ugi Amide Dianion: An Entry into Pyrrolidinone and Benzoindolizidine Alkaloid Analogues
Alaa Zidan, Marie Cordier, Abeer M. El-Naggar, Nour E. A. Abd El-Sattar, Mohamed Ali Hassan, Ali Khalil Ali And Laurent El-Kaïm
Org. Lett. 2018, 20, 2568-2571.

139. Metal-Free Deamidative Ugi Access to Isoindolinones
Samira Baaziz, Mansour Solè Kerim, Marie Cordier, Lamourl Hammal and Laurent El Kaïm
Synlett 2018, DOI: 10.1055/s-0037-1610189.

138. 4-Aminoprimidine librairies from the Ugi-Smiles reaction of thiouracils
Madjid Ait Sidhoum, Laurent El Kaïm and Laurence Grimaud
Tetrahedron 2018, in press, 10.1016/j.tet.2018.04.058.

137. Propargylation of Ugi Amide Dianion: An Entry into Pyrrolidinone and Benzoindolizidine Alkaloid Analogues
Alaa Zidan, Marie Cordier, Abeer M. El-Naggar, Nour E. A. Abd El-Sattar, Mahamed Ali Hassan, Ali Khalil Ali and Laurent El Kaïm
Org. Lett. 2018, 20, 2568-2571.

136. TiCl4 -Mediated Synthesis of 3,4-Hetero-Disubstituted Isocoumarins by Means of Isocyanide Insertion Reactions
Sudipta Ponra, Aude Nyadanu, Sylvie Maurin, Laurent El Kaïm, Laurence Grimaud, Maxime R. Vitale
Synthesis 2018, 50, 1331-1342.

135. Mannich reaction of trifluoroacetaldehyde hydrazones, a useful entry to trifluoromethyl substituted heterocycles
Shuanglong Jia and Laurent El Kaïm
Org. Biomol. Chem. 2018, 16, 1457-1460.

134. Palladium-catalysed O -Allylation of α-Hydroxyphosphonates: An Expedient Entry into Phosphono-oxaheterocycles
Mansour Dolé Kerim, Martin Cattoen, Nicolas Fincias, Aurélie Dos Santos, Stellios Arseniyadis and Laurent El Kaïm
Adv. Synth. Catal. 2018, 360, 449-454.

133. Passerini/Tsuji-Trost strategy towards pyrrole derivatives
N. Narboni, L. El Kaim
J. Org. Chem. 2017, 4242-4246 
10.1002/ejoc.201700653

132. Nef-Perkow Cascade towards Imidazo Phosphate Derivatives
Somayeh Ghorbani, Ebrahim Soleimani, Laurent El Kaïm,
Tetrahedron Lett. 2017, 58, 4595-4597, 10.1016/j.tetlet.2017.10.055

131. Nef–Perkow–Mumm Cascade towards Imido Phosphate Derivatives
Aurélie Dos Santos, Marie Cordier, Laurent El Kaïm
Synlett, 2017, 28, 2637-2641. DOI: 10.1055/s-0036-1590856

130. β-Lactam Synthesis through Diodomethane Addition to Amide Dianions
A. Zidan, J. Garrec, M. Cordier, A. M. El Naggar, N. E. A. El-Sattar, A. K. Ali, M. A. Hassan, L. El Kaïm
Angew. Chem Int. Ed, 2017, 56, 12179-12183. DOI: 10.1002/anie.201706315

129. N-N bond formation in Ugi Processes: from nitric acid to libraries of Nitramines
V. Mercalli, A. Nyadanu, M. Cordier, G. C. Tron, L. Grimaud, L. El Kaïm
Chem. Commun., 2017,53, 2118-2121. DOI: 10.1039/C6CC10288C

128. Ugi–Smiles Couplings of Purine Derivatives
A. Ben Abdessalem, R. Abderrahim, A. Dos Santos, L. El Kaïm, L. Grimaud
Synlett, 2017, 28, 691-694. DOI: 10.1055/s-0036-1588117

127. Selective Tsuji-Trost type C-allylation of hydrazones: A straightforward entry into 4,5-dihydro pyrazoles
E. H. El Mamouni, M. Cattoen, M. Cordier, J. Cossy, S. Arseniyadis, H. Ilitki, L. El Kaïm
Chem. Commun., 2016, 52, 14490 – 14493. DOI: 10.1039/C6CC08171A

126. Optimized Conditions for Passerini-Smiles Reactions and Applications to Benzoxazinone Syntheses
E. Martinand-Lurin , A. Dos Santos, E. Robineau , P. Retailleau , P. Dauban , L. Grimaud, L. El Kaïm
Molecules 2016, 21(9), 1257; doi:10.3390/molecules21091257

125. Multiple Roles of Isocyanides in Imidoylative Palladium-Catalyzed Couplings - A Mechanistic Study
L. A. Perego, P. Fleurat-Lessard, L. El Kaïm, I. Ciofini, L. Grimaud
Chem. Eur J. 2016, 22, 15491-15500. 10.1002/chem.201602913

124. TiCl4-Mediated Preparation of Thiophtalide Derivatives via Formal Thio-Passerini Reactions
S. Ponra, A. Nyadanu, L. El Kaïm, L. Grimaud, M. R Vitale
Org. Lett. 2016, 18, 4060-4063. DOI: 10.1021/acs.orglett.6b01937

123. Passerini/Friedel-Crafts route towards Indole Derivatives
E. H. El Mamouni, A. Dos Santos, L. El Kaïm, H. Ilitki
Synlett, 2016, 27, 2571-2574. DOI : 10.1055/s-0035-1561497

122. Piperazine as Leaving Group in A3 Adducts : Fast Access to Alkynyl Indoles
M. Dolé Kérim, L. El Kaïm
Synlett, 2016, 27, 1572-1576. DOI: 10.1055/s-0035-1561396

121. A Non oxydative pathway towards -ketoamides
A. Ben Abdessalem, R. Abderrahim, L. El Kaïm
Synlett, 2015, 26, 2537-2540. DOI: 10.1055/s-0035-1560632.

120. The Ugi Reaction of Cyanoacetic Acid as a Route to Tetramic Acid Derivatives
N. V. Alvarez-Rodríguez, A. Dos Santos, L. El Kaïm, R. Gámez-Montaño
Synlett 2015; 26(16): 2253-2256. DOI: 10.1055/s-0035-1560050

119. Passerini/Tsuji-Trost strategies towards achieving lactams and cyclopentane derivatives
M. Cordier, A. Dos Santos, L. El Kaïm, N. Narboni
Chem. Commun., 2015, 51, 6411-6414. DOI: 10.1039/c5cc00584a

118. Formal [3+2] cycloaddition of Ugi adducts towards pyrrolines
A. Ben Abdessalem, R. Abderrahim, A. Agrebie, A. Dos Santos, L. El Kaïm, A. Komesky
Chem. Commun., 2015, 51, 1116-1119. DOI: 10.1039/C4CC08282F

117. Synthesis, antimicrobial and antioxidant activities of imidazotriazoles and new multicomponent reaction toward 5-amino-1-phenyl[1,2,4]triazole derivatives
M. Aouali, D. Mhalla, F. Allouche, L. El Kaïm, S. Tounsi, M. Trigui, F. Chabchoub
Medicinal Chemistry Research, 2015, 24, 2732-2741. DOI:10.1007/s00044-015-1322-z

116. The Ugi–Smiles and Passerini–Smiles Couplings: A Story About Phenols in Isocyanide- Based Multicomponent Reactions
L. El Kaïm, L. Grimaud
Eur. J. Org. Chem. 2014 , 7749–7762. DOI: 10.1002/ejoc.201402783

115. Benzoxazinone synthesis via Passerini-Smiles couplings
E. Martinand-Lurin, L. El Kaïm, L. Grimaud
Tetrahedron Letters, 2014, 5144-5146. DOI: 10.1016/j.tetlet.2014.07.088

114. Reductive Passerini/Tsuji–Trost Strategy towards β,γ-Unsaturated Amides
A. Dos Santos, L. El Kaïm
Synlett 2014, 25, 1901-1903. DOI: 10.1055/s-0033-1340187

113. Pyrrolidinone and piperidinone isocyanides from isocyanoesters
M. Ait Sidhoum, A. Dos Santos, L. El Kaïm, L. Legras
Eur. J. Org. Chem. 2014, 4949-4952. DOI: 10.1002/ejoc.201402572

112. The Nef reaction of isocyanides
F. La Spisa, G. C. Tron, L. El Kaïm
Synthesis, 2014, 46, 829-841. DOI: 10.1055/s-0033-1338596

111. Nitrile synthesis through catalyzed cascades involving acid-nitrile exchange reaction
D. Cartigny, L. El Kaïm, L. Grimaud, P. Marion, R. Jacquot
Synthesis, 2014, 46, 1802-1806. DOI: 10.1055/s-0033-1341227

110. Kinetic Data on the Synergetic Role of Amines and Water in the Reduction of Phosphine Ligated-Palladium(II) to Palladium(0)
C. Amatore, L. El Kaïm, L. Grimaud, A. Jutand, A. Meigné, G. Romanov
Eur. J. Org. Chem., 2014, 4709-4713. DOI: 10.1002/ejoc.201402519

109. Synthesis of 2-Tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a One-Pot Ugi-Azide/Pictet–Spengler Process
L. E. Cárdenas-Galindo, A. Islas-Jácome, N. V. Alvarez-Rodríguez, L. El Kaïm, R. Gámez-Montaño
Synthesis 2014, 46, 49-56. DOI: 10.1055/s-0033-1340051

108. Double Smiles rearrangement of Passerini adducts towards benzoxazinones
E. Martinand-Lurin, A. Dos Santos, L. El Kaïm, L. Grimaud, P. Retailleau
Chem. Commun. 2014, 50, 2214 – 2217. DOI: 10.1039/C3CC49022J

107. Pyrrolo[2,3-d]pyrimidine Synthesis Through Activation of N-Benzyl Groups by Distal Amides
L. El Kaïm, L. Grimaud, S. Wagschal
Org. Biomol. Chem. 2013, 11, 6883–6885. DOI: 10.1039/C3OB41477A

106. Sc(OTf)3 promoted multicomponent synthesis of fluorescent imidazo[1,2-c]pyrazolo[3,4-d]pyrimidine
A. Agrebi , F. Allouche , F. Chabchoub , L. El Kaïm , S. Alves , C. Baleizão , J. P. Farinha
Tetrahedron Lett. 2013, 54, 4781-4784. DOI: 10.1016/j.tetlet.2013.06.136

105. Substituent Effects in Ugi-Smiles Reactions
N. Chéron, R. Ramozzi, L. El Kaïm, L. Grimaud, P. Fleurat-Lessard.
J. Phys. Chem. A 2013, 117, 8035-8042. DOI: 10.1021/jp4052227

104. Cyclization cascade of hydrazono Ugi adducts towards pyrazoles
A. Agrebi, L. El Kaïm, F. Allouche, F. Chabchoub
Eur. J. Org. Chem. 2013, 5805-5808. DOI: 10.1002/ejoc.201300787

103. Efficient synthesis of 1,5-disubstituted-1H-tetrazoles by an Ugi-azide process
L. E. Cárdenas-Galindo, A. Islas-Jácome, C. J. Cortes-García, L. El Kaïm, R. Gámez-Montaño
J. Mex. Chem. Soc. 2013, 57 (4), 283-289.

102. Lewis acid mediated fragmentation of tetrazoles towards triazoles
L. El Kaïm, L. Grimaud, P. Patil
Eur. J. Org. Chem. 2013, 4752-4755. DOI: 10.1002/ejoc.201300620

101. Three-component metal-free arylation of isocyanides
U. M. Basavanag, A. Dos Santos, L. El Kaïm, R. Gamez-Montejo, L. Grimaud
Angew. Chem. Int. Ed., 2013, 52, 7194-7197. DOI: 10.1002/anie.201302659.

100. Metal-free aerobic oxidation of benzazole derivatives
A. Dos Santos, L. El Kaïm, L. Grimaud
Org. Biomol. Chem. 2013, 11, 3282-3287. DOI:10.1039/C3OB27404G

99. Oxazole Synthesis from isocyanides
Laurent El Kaïm, Laurence Grimaud, Pravin Patil
Synlett 2012, 23, 1361-1363. DOI: 10.1055/s-0031-1290939

98. Challenging 50 Years of Established Views on Ugi Reaction: A Theoretical Approach.
Nicolas Chéron, Romain Ramozzi, Laurent El Kaïm, Laurence Grimaud, Paul Fleurat-Lessard
J. Org. Chem. 2012, 77, 1361–1366. DOI: 10.1021/jo2021554

97.Ugi-Smiles couplings of 4-substituted pyridine derivatives: a fast access to chloroquine analogues
Laurent El Kaïm, Laurence Grimaud, Patil Pravin
Org. Lett. 2012, 14, 476-478. DOI: 10.1021/ol202974w

96. Palladium catalyzed ring-opening of aminocyclopropyl Ugi adducts
Aurélie Dos Santos, Laurent El Kaïm, Laurence Grimaud, Romain Ramozzi
Synlett 2012, 23, 438-442. DOI 10.1055/s-0031-1290312

95. Ugi-Smiles coupling of thiouracil derivatives towards 2,4-diamino pyrimidines
Madjid Ait Sidhoum, Laurent El Kaïm, Laurence Grimaud
Synlett, 2012, 632-636. DOI: 10.1055/s-0031-1290347

94. Four-component synthesis of indazole through Ugi-azide coupling
Laurent El Kaïm*, Laurence Grimaud*, Srinivas Reddy Purumandla
Synlett, 2012, 23, 295-297. DOI: 10.1055/s-0031-1290075

93. Xanthate Based Radical Cascade Toward Multicomponent Formation of Pyrrolopyrimidines
El Kaïm, L.; Grimaud, L.; Pravin, P.
Molecules 2011, 16, 9261-9273. DOI:10.3390/molecules16119261

92- Evidences for the Key-Role of Hydrogen Bonds in SnAr
N. Chéron, L. El Kaïm, L. Grimaud, P. Fleurat-Lessard
Chem. Eur. J. 2011, Vol 17, 14929-14934. DOI: 10.1002/chem.201102463

91- A Density Functional Theory Study of the Nef-Isocyanide Reaction: Mechanism, Influence of Parameters and Scope
N. Chéron, L. El Kaïm, L. Grimaud, P. Fleurat-Lessard
J. Phys. Chem. A, 2011, 115, 10106-10112. DOI: 10.1021/jp205909d

90-Three-component strategy towards 5-membered heterocycles from isocyanide dibromides
El Kaïm, L.; Grimaud, L.; Pravin, P.
Org. Lett. 2011, 13, 1261-1263. DOI: 10.1021/ol200003u

89-Copper-triggered oxidative cascade as Ugi post-condensation towards pyrazoles
Aurélie Dos Santos, Laurent El Kaïm*, Laurence Grimaud* and Caroline Ronsseray
Beilstein J Org. Chem. 2011, 7, 1310-1314. doi:10.3762/bjoc.7.153

88- Phosphite mediated synthesis of benzimidazoles: a one-pot 4-component approach from nitrophenols
Laurent El Kaïm*, Laurence Grimaud*, Srinivas Reddy Purumandla
Eur. J. Org. Chem. 2011, 6177-6180. DOI: 10.1002/ejoc.201100939

87- Allyl and benzyl dance under basic conditions
Laurent El Kaïm*, Laurence Grimaud*, Srinivas Reddy Purumandla
Synlett 2011, 1816-1820. DOI: 10.1055/s-0030-1260964

86- Copper-catalyzed aerobic oxidative cyclization of hydrazones to pyrazolidinones
Dos Santos, A. ; El Kaïm, L. ;Grimaud, L. ; Ronsseray, C.
Eur. J. Org. Chem. 2011, 17, 3117-3121. DOI: 10.1002/ejoc.201100261

85- Straightforward four-component access to spiroindolines
El Kaïm,L.; Grimaud,L. ; Le Goff, X-F. ; Menes-Arzate, M. ; Luis D. Miranda
Chem. Communication 2011, 47, 8145-8147. DOI: 10.1039/C1CC12236C

84- A new multicomponent reaction for the synthesis of pyridines via cycloaddition of azadienes and ketenimines
Coffinier, D.; El Kaïm, L.; Grimaud, L.; Ruijter, E.; Orru, R. V. A.
Tetrahedron Lett. 2011, 52, 3023-3025. DOI: 10.1016/j.tetlet.2011.04.007

83- Multicomponent Synthesis of Fused Benzimidazolopiperazines
El Kaïm, L.; Grimaud, L.; Purumandla, S. R.
J. Org. Chem. 2011, 76, 4728-4733. DOI: 10.1021/jo200397m

82- Palladium catalyzed ring opening of furans as a route to ,-unsaturated aldehydes
L. El Kaïm, L. Grimaud, S. Wagschal
Chem. Communication, 2011,47, 1887-1889. DOI: 10.1039/C0CC04164E

81- Smiles cascades towards heterocyclic scaffolds
L. El Kaïm, L. Grimaud, X. F. Le Goff, A. Schiltz
Org. Lett. 2011, 13, 534-536. DOI: 10.1021/ol1028817

80- Isonitriles et réactions multicomposants
L. El Kaïm, J. Zhu
Sciences et Techniques de l’Ingénieurs, 2010.

79- Ammonia in Ugi-Smiles and Ugi Couplings
A. Barthelon, L. El Kaïm, M. Gizzi, L. Grimaud
Synlett 2010, 2784-2788. DOI: 10.1055/s-0030-1259004

78- Nef-Perkow access to indolizine derivatives
D. Coffinier, L. El Kaïm, L. Grimaud
Synlett 2010, 2474-2476. DOI: 10.1055/s-0030-1258569

77- A new pyridine synthesis from azoenamines
Didier Coffinier, Laurent El Kaïm, Laurence Grimaud, Simon Hadrot
Tetrahedron Lett. 2010, 51, 6186-6188. DOI:10.1016/j.tetlet.2010.09.098

76- Three-component Fischer indole synthesis
Laurent El Kaïm, Laurence Grimaud, Caroline Ronsseray
Synlett 2010, 2296-2298. DOI: 10.1055/s-0030-1258037

75- Ugi-Smiles couplings in water
Laurent El Kaïm, Laurence Grimaud, Srinivas R. Purumandla
Tetrahedron Lett. 2010, 51, 4962-4964. DOI:10.1016/j.tetlet.2010.07.058

74 - Efficient Synthesis of Azaspirodienones by Microwave-Assisted Radical Spirocyclization of Xanthate-Containing Ugi Adducts
Gamez-Montano, Rocio; Ibarra-Rivera, Tannya; Kaïm, Laurent El; Miranda, Luis D.
Synthesis 2010; 1285-1290. DOI: 10.1055/s-0029-1218700

73- Towards new pyrrolo[2,3-d]pyrimidines scaffolds
El Kaïm Laurent , Grimaud Laurence, Wagschal Simon
J. Org. Chem. 2010 75, 5343-5346. DOI: 10.1021/jo100759b

72- 1,2,4-Triazole synthesis via amidrazones
Laurent El Kaïm, Marion Gizzi, Laurence Grimaud
Synlett 2010, 1771-1774. DOI: 10.1055/s-0030-1258117

71- New xanthate-based radical cyclization onto alkynes
Laurent El Kaïm, Laurence Grimaud, Luis D. Miranda, Emilie Vieu, M.-Angeles Cano-Herrera and Karel Perez-Labrada
Chem. Commun. 2010, 46, 2489-2491. DOI: 10.1039/B924207D

70- Four-component Synthesis of Imidazolinium-fused Heterocycles from Ugi-Smiles Couplings
Anaëlle Barthelon, Xavier-Frédéric Legoff, Laurent El Kaïm, Laurence Grimaud
Synlett, 2010, 153-157. DOI: 10.1055/s-0029-1218550

69- Ugi-Smiles Couplings: New Entries to N-Aryl Carboxamide Derivatives
Laurent El Kaïm, Laurence Grimaud
Mol. Div. 2010, 14 , 855-867. DOI: 10.1007/s11030-009-9175-3

68- One-pot synthesis of oxazoles using isocyanide surrogates
Laurent El Kaïm, Laurence Grimaud, Aurélie Schiltz
Tetrahedron Lett. 2009, 50, 5235-5237. DOI:10.1016/j.tetlet.2009.07.001

67- “Isocyanide-free” Ugi reactions
Laurent El Kaïm, Laurence Grimaud, Aurélie Schiltz
Org. Biomol. Chem. 2009, 7, 3024. DOI: 10.1039/B908541F

66- Unconventional oxazole formation from isocyanides
Aurélie dos Santos, Laurent El Kaïm, Laurence Grimaud, Caroline Ronsseray
Chem. Comm. 2009, 3907-3909. DOI: 10.1039/b904699b

65- Isocyanide-based three-component keteneimine formation
D. Coffinier, L. El Kaïm, L. Grimaud
Org. Lett. 2009, 11, 1825-1827. DOI: 10.1021/ol9004432

64-Isocyanide based Multicomponent reaction “without“ isocyanides
L. El Kaïm, L. Grimaud, A. Schiltz
Synlett 2009,1401-1404. DOI: 10.1055/s-0029-1217184

63- Three-component Nef/Huisgen access to 1,2,4-triazoles
L. El Kaïm, L. Grimaud, S. Wagschal
Synlett, 2009, 1315-1317. DOI: 10.1055/s-0028-1216738

62-Beyond the Ugi reaction: less conventional interactions between isocyanides and iminium species
L. El Kaïm, L. Grimaud
Tetrahedron 2009, 65, 2153-2171. DOI: 10.1016/j.tet.2008.12.002.

61- Three component Ugi-Smiles couplings of cyclic imines
El Kaïm, L.; Grimaud, L.; Oble, J. Wagschal, S.
Tetrahedron Lett. 2009, 50, 1741-1743. DOI: 10.1016/j.tetlet.2009.01.145

60- New benzotriazole and benzimidazole scaffolds from Ugi-Smiles couplings of isocyanides
El Kaïm, L.; Grimaud, L.; Coffinier, D.
Org. Lett. 2009, 11, 995-997. DOI: 10.1021/ol8029438

59- Thiols in Ugi- and Passerini-Smiles-type couplings
A. Barthelon, L. El Kaïm, M. Gizolme, L. Grimaud
European J. Org. Chem. 2008, 5974-5987. DOI: 10.1002/ejoc.200800859.

58- New MCR-Heck-isomerization Cascade towards Indole
Laurent El Kaïm, Marion Gizzi, Laurence Grimaud
Org. Lett. 2008, 10, 3417-3419. DOI: 10.1021/ol801217a

57-Ugi /Smiles access to pyrazine scaffolds
Anaelle Barthelon, Aurélie Dos Santos, Laurent El Kaïm, Laurence Grimaud
Tetrahedron Lett. 2008, 49, 3208-3211. DOI: 10.1016/j.tetlet.2008.03.100

56-Isocyanide addition to acyl phosphonates: a formal Passerini reaction of acyl chlorides
Didier Coffinier, Laurent El Kaïm, Laurence Grimaud
Synlett. 2008, 1133-1136. DOI: 10.1055/s-2008-1072726

55- New palladium-catalyzed aerobic oxidative cleavage and cyclization of N-aryl peptide derivatives
Laurent El Kaïm, Rocio Gamez-Montano, Laurence Grimaud Tannya Ibarra-Rivera
Chem. Commun. 2008, 1350-1352. DOI: 10.1039/B716849G

54- From simple Ugi adducts to indanes and -amidomalonates: new manganese (III) induced radical cascades
L. El Kaïm, L. Grimaud, E. Vieu
Org. Lett. 2007, 9, 4171-4173. DOI: 10.1021/ol701678d

53-Ugi-Smiles access to quinoxalines derivatives
J. Oble, L. El Kaïm, M. Gizzi, and L. Grimaud
Heterocycles, 2007, 73, 503-517. DOI: 10.3987/COM-07-S(U)26

52-New Ugi-Smiles-metathesis strategy towards the synthesis of pyrimido azepines
L. El Kaïm, M. Gizolme, L. Grimaud, J. Oble
J. Org. Chem. 2007, 72, 5835-5838. DOI: 10.1021/jo070706c

51-Smiles rearrangements in Ugi and Passerini type couplings: new multicomponent accesses to O- and N aryl amides
L. El Kaïm, M. Gizolme, L. Grimaud, J. Oble
J. Org. Chem, 2007, 72, 4169-4180. DOI: 10.1021/jo070202e

50-New Benzothiazole and Benzoxazole Scaffolds from the Ugi–Smiles Couplings of Heterocyclic Thiols
L. El Kaïm, M. Gizolme, L. Grimaud, J. Oble
Synlett, 2007, 465-469. DOI: 10.1055/s-2007-968027.

49- New Ugi/Pictet–Spengler Multicomponent Formation of Polycyclic Diketopiperazines from Isocyanides and a-Keto Acids
L. El Kaïm, M. Gageat, L. Gaultier, L. Grimaud
Synlett, 2007, 500-502. DOI: 10.1055/s-2007-968026.

48- New indolizines template from the Ugi reaction
L. El Kaïm, M. Gizolme, L. Grimaud
Synlett, 2007, 227-230. DOI: 10.1055/s-2007-968011

47- Ugi /xanthate cyclisations as a radical route to lactam scaffolds
L. El Kaïm, L. Grimaud, L.D. Miranda, E. Vieu
Tetrahedron Letters, 2006, 47, 8259-8261. DOI: 10.1016/j.tetlet.2006.09.123

46- Direct access to heterocyclic scaffolds by new multicomponent Ugi Smiles coupling
L. El Kaïm, M. Gizolme, L. Grimaud, J. Oble
Org. Lett. 2006, 8, 4019-4021.DOI: 10.1021/ol061605o

45-O-Arylative Passerini reaction
L. El Kaïm, M. Gizolme, L. Grimaud
Org. Lett. 2006, 8, 5021-5023.DOI: 10.1021/ol0617502

44-New ortho-quinone methide formation: application to three-component coupling of isocyanides, aldehydes and phenols
L. El Kaïm, L. Grimaud, J. Oble
Org. Biomol. Chem., 2006, 4, 3410 – 3413. DOI: 10.1039/B610229H

43-Solvent free preparation of amidophosphonates from isocyanides
L. El Kaïm, L. Grimaud, S. Hadrot

Tetrahedron Letters, 2006, 47, 3945-3947. DOI:10.1016/j.tetlet.2006.03.151

42- Phenol-Ugi-Smiles Systems: Highly efficient strategies for the multicomponent N-arylation of primary amines with isocyanides, aldehydes and phenols
L. El Kaïm, L. Grimaud, J. Oble
Angew. Chem., Int. Ed, 2005, 44, 7961-7964.DOI: 10.1002/anie.200502636

41- Towards the Synthesis of Paulitin: New Insights into the Enyne-Metathesis Mechanism
E. Vedrenne; F. Royer; J. Oble; L. El Kaïm; L. Grimaud
Synlett 2005, 2379-2380. DOI: 10.1055/s-2005-872261.

40- Formation of new phosphates from aldehydes by a DBU-catalysed Phospha-Brook rearrangement in a polar solvent
L. El Kaïm, L. Gaultier, L. Grimaud, A. Dos Santos
Synlett 2005, 2335-2336. DOI: 10.1055/s-2005-872670

39- Dramatic effect of boron-based Lewis acid in cross-metathesis reactions
E. Vedrenne, H. Dupont, S. Oualef, L. El Kaïm, L. Grimaud
Synlett 2005, 4, 670-672. DOI: 10.1055/s-2005-862375

38- New access to fluorinated ketoglycolic acid derivatives from trifluoropyruvamides
T. Colin, L. El Kaïm, L. Gaultier, L. Grimaud, L. Gatay
Tetrahedron Lett., 2004, 45, 5611-5613. DOI: 10.1016/0040-4039(95)02152-3

37- From isocyanides to trichloropyruvamides : Application to new preparation of Oxamide dérivatives
L. El Kaïm, L. Gaultier, L. Grimaud, E. Vieu
Tetrathedron Lett, 2004, 45, 8047-8048. DOI: 10.1016/j.tetlet.2004.08.169

36-First carbamates conversion to amides by simple alkyl group transfer from trialkylalanes
L. El Kaïm, L. Grimaud, A. Lee, Y. Perroux, C. Tirla
Org. Lett. 2004, 6, 381-383. DOI: 10.1021/ol036234f

35-New straightforward quinoline synthesis from the Mannich reaction of -ketohydrazones
V. Baillez, L. El Kaïm, V. Michaut
Synthetic Communication, 2004, 34, 109-118. DOI: 10.1081/SCC-120027244

34-New trimethylaluminum induced Mannich type reaction of hydrazones.
Laurent El Kaïm, Laurence Grimaud, Yannick Perroux, Cornelia Tirla
J. Org. Chem., 2003, 68, 8733-8735.

33-New insight into the azaenamine behavior of N-Arylhydrazones: first Aldol and improved Mannich reactions with unactivated aldehydes
Laurent El Kaïm, Laurent Gautier, Laurence Grimaud, Valerie Michaut
Synlett, 2003, 1844-1846.

32-Selective Domino Ring-Closing Metathesis-Cross-Metathesis Reactions between Enynes and Electron-Deficient Alkenes
Royer, F.; Vilain, C.; ElKaïm, L.; Grimaud, L.
Org. Lett. 2003, 5, 2007-2009.

31-The Mannich Reaction of Hydrazones: Improved Reactivity under Solvent-free Conditions
L. El Kaïm, L. Gautier, L. Grimaud, L. M. Harwood and V. Michaut
Green Chem., 2003, 5, 477 – 479.

30- Amines addition to a-nitrohydrazones : application to amidrazones and triazoles formation
L. El Kaïm, L. Grimaud, N.K. Jana, F. Mettetal, C. Tirla
Tetrahedron Letters, 2002, 43, 8925-8927.

29- Studies towards the synthesis of Fipronil analogues: improved decarboxylation of -hydrazonoacid derivatives
J.E. Ancel, L. El Kaïm, A. Gadras, L. Grimaud, N.K. Jana
Tetrahedron Letters, 2002, 8319-8322.

28- a-Nitrohydrazones:versatile intermediates for phosphonate derivatives formation from primary nitro compounds
L. ElKaïm, L. Grimaud, N.K. Jana, C. Tirla
Tetrahedron Letters, 2002, 2037-2038.

27-The Mannich reaction of Hydrazones Amenable to Solid Phase Synthesis : A powerful Tool for Heterocycle Preparation
V. Atlan, L. ElKaïm, L. Grimaud, N.K. Jana, A. Majee
Synlett, 2002, 352-354.

26-The use of hydrazones for efficient mannich type coupling with aldehydes and secondary amines.
V. Atlan, H. Bienaymé, L. El Kaïm, A. Majee
J. Chem. Soc, Chem. Commun., 2000, 1585-1586.

25-New Versatile Approach to a-Hydrazonoesters and Aminoacids Derivatives trough a Modified Japp-Klingemann Reaction
V. Atlan, L. El Kaïm, C. Supiot
Chem. Comm., 2000, 1385-1386.

24-Trichloroacylhydrazones: New Straightforward Preparation of Pyrazoles from Ketoesters
L. ElKaïm, S. Lacroix
Synlett, 2000, 353-354.

23-A New Straightforward Formation of Aminopyrazoles from Isocyanides
V. Atlan, C. Buron, L. ElKaïm
Synlett, 2000, 489-490.

22-Dramatic Solvent Effect in the Multicomponent Reaction of Nitro Compounds with Isocyanides
P. Dumestre, L. ElKaïm
Tetrahedron Letters, 1999, 7985-7986.

21-Trichloroacetyl Hydrazones: New highly reactive alkylating Agents
V. Atlan, L. El Kaïm*, S. Lacroix, R. Morgentin
Chem. Commun., 1999, 1893-1894.

20-A New Multicomponent Reaction of Nitro Compounds with isocyanides
Paul Dumestre, Laurent El Kaïm, Ariane Grégoire
Chem. Comm., 1999, 775-776.

19-Mechanical Aspects of the Phosphotriesterase Activity of Human Butyrylcholinesterase G117H Mutant
Christine Albaret, Patrick Masson, Clarence A. Broomfield, Laurent El Kaïm, Pierre-Louis Fortier
Structure and Function of Cholinesterases and Related Proteins, 1998, pp 399-405

18-Trichloroacetic acid Hydrazones I: New formation of 1,3,4-oxadiazoles from aldehydes.
L. ElKaïm, I. Le Menestrel, R. Morgentin
Tetrahedron Letters, 1998, 39, 6885-6888.

17-Trifluoropyruvamides from Isocyanides and Trifluoroacetic Anhydride.
L. ElKaïm, E. Pinot-Périgord
Tetrahedron, 1998, 54, 3799-3806.

16- Thiophenol promoted radical cyclisation onto hydrazones.
L. El Kaïm, A. Gacon, A. Perroux
Tetrahedron Letters, 1998, 39, 371-374.

15- A New Straightforward formation of Aminoisoxazoles from Isocyanides.
C. Buron, L. ElKaïm, A. Uslu
Tetrahedron Letters,1997,8027-8030.

14-Diazo Esters Addition to Trifluoropyruvamides : New Access to Highly Functionalized Trifluoromethyl Epoxides and Diazo Compounds
L. El Kaïm, C. Ollivier
Synlett, 1997, 797.

13- A New conversion of Primary Nitro Compounds into Nitriles
L. ElKaïm, A. Gacon
Tetrahedron Letters, 1997, 38, 3391-3394.

12- An Unprecedent Radical Reaction of Benzotriazole Derivatives. A New Efficient Method for the Generation of Iminyl Radicals.
L. El Kaïm; C. Meyer
Journal of Organic Chemistry, 1996, 61, 1556-1557.

11- New Access to Fluorinated Glycolic Acid Derivatives from Trifluoropyruvamides.
L. El Kaïm, S. Guyoton, C. Meyer
Tetrahedron Letters, 1996, 37, 375-378.

10-Trifluoromethyl Ketones from Carboxylic Acids. Part II
A versatile Access to Trifluoromethylated Heterocycles.
J. Boivin; L. El Kaïm; S. Z. Zard
Tetrahedron, 1995, 51, 2585-2592.

9-A New and efficient Synthesis of Trifluoromethyl ketones from Carboxylic acids. Part I.
J. Boivin; L. El Kaïm; S. Z. Zard
Tetrahedron, 1995, 51, 2573-2584.

8-A short Total Synthesis of Oestrone Derivatives. A Novel 1,3-rearrangement of an allylic Nitro Group.
B. Barlaam, J.B. Boivin, L. ElKaïm, S. Elton Far, S.Z. Zard
Tetrahedron, 1995, 51, 1675-1684.

7-Trifluoropyruvamides from Isocyanides and Trifluoroacetic Anhydride
L.ElKaïm
Tetrahedron Letters, 1994, 35, 6669-6670.

6-Procédé de Synthèse d'Isocyanates d'Alkyle (Enveloppe Soleau)
J. Boivin; L. El Kaïm; J.P. Senet; S. Z. Zard.

5-Directionality and stereodivergent aldol additions
Nguyen Trong Anh; L. El Kaïm; B.T. Thanh; F. Maurel; J.P. Flament
Bull. Soc. Chim. Fr., 1992, 129, 468-477.

4-An Expedient Access to Trifluoromethyl ketones from Carboxylic Acids.
J. Boivin; L. El Kaïm; S. Z. Zard
Tetrahedron Lett. 1992, 33, 1285.

3-A New Practical Method for the Synthesis of Acetylenes
J. Boivin ; L. El Kaïm; P.G. Ferro; S. Z. Zard
Tetrahedron Lett. 1991, 32, 5321.

2-An Expedient Total Synthesis of (+)-Estrone Derivatives
B. Barlaam, J. Boivin; L. El Kaïm; S. Z. Zard
Tetrahedron Lett. 1991, 32, 623.

1-A Novel Thermal Rearrangement of Allylic Nitro Dervatives into Allylic Alcohols.
J. Boivin; L. EL Kaïm; J. Kervagoret; S.Z. Zard
J. Chem. Soc., Chem. Commun., 1989,1006